Mental health status of infertility patients with varicocele / 中华男科学杂志

<p><b>OBJECTIVE</b>To study the mental health status of infertility patients with varicocele and its relationship with infertility.</p><p><b>METHODS</b>Using Hospital Anxiety and Depression scale (HAD), we assessed the psychological status of 110 infertility patients with varicocele, identified the risk factors of anxiety and depression in these patients, and analyzed the correlation among psychological and other relevant factors. Meanwhile, we recruited 61 age-matched normal fertile men as controls for comparative analysis. We also conducted logistic regression analysis on the mental health status of the 106 infertility patients with varicocele.</p><p><b>RESULTS</b>The prevalence rates of anxiety were 61.32% and 13.79%, while those of depression 37.73% and 6.90% in the infertile patients and normal fertile controls, respectively, significantly higher in the former than in the latter (P < 0.05). Logistic regression analysis showed that the main risk factors of anxiety and depression of the infertile patients were the number of times they sought medical care and the severity of their testis disorders.</p><p><b>CONCLUSION</b>Infertility patients with varicocele have psychological disorders, which are particularly associated with the frequency of the patients' clinic visit and the severity of their testis disorders.</p>

Regulatory effects of cyclosporin A and tacrolimus on the immunological gene expressions in renal transplant recipients / 中国医学科学院学报

<p><b>OBJECTIVE</b>To observe the change of Th immunological gene in renal transplant recipients after the treatment of cyclosporine (CsA) and tacrolimus (FK506).</p><p><b>METHODS</b>The peripheral blood lymphacytes just before and 24 hours after CsA and FK506 treatment were isolated. The total RNA of them were reverse-transcripted and examined by real-time quantity PCR array. The results were analyzed by bioinformatic methods.</p><p><b>RESULTS</b>The TLR4, CEBPB, IL4R, IL1R1,IL18R1,and IL1R2 genes were remarkably upregulated, whereas IL-2, CCL5, CD27, CCR5, CCR4, CD4, RPL13A, TGFB3, CD86, CCR3, STAT1, NFATC2IP, IL23A, IL15, IRF4, and TFCP2 were downregulated 24 hours after CsA treatment. The IL18, IL7, PTPRC, TNFSF4, SPP1, GFI1, TLR4, IL13RA1, TNF, INHBA, LAG3, IL13, IL1R1, SOCS5, IL10, YY1, TBX21, FASLG, IL18R1, and IL1R2 genes were remarkably upregulated, whereas IL-2, IL-3, IL-4, IL-6,CCR5, CD4, CD27, CD40LG, IL15, CCR3, CD86, CCR4, and IRF4 were obviously downregulated 24 hours after FK506 treatment.</p><p><b>CONCLUSION</b>CsA and FK506 exert their therapeutic effectiveness by regulating the expressions of a series of target genes.</p>

Status and change pattern of kidney transplantation: one center research / 中国医学科学杂志(英文版)

<p><b>OBJECTIVE</b>To retrospectively investigate the distribution in kidney transplantation for fifteen years in Peking Union Medical College Hospital.</p><p><b>METHODS</b>We conducted a descriptive research counting up the number of patients who received kidney transplantation each year in our hospital during 1995 and 2010.</p><p><b>RESULTS</b>The first kidney transplantation in our hospital occurred in the 1960s. The number of kidney transplantation increased until reaching a maximum of 47 grafts in 2001; since then the number fell.</p><p><b>CONCLUSIONS</b>With the decreased number of kidney transplantation, we have realized the shortage of transplantable organs is very serious. The continuing transplant shortage requires major efforts to expand the donor pool. Donation after cardiac death offers the potential to enlarge the donor pool, but we need to strictly control the criteria for potential donors.</p>